Intermediary Metabolism

Intermediary Metabolism and Energetics during Murine Early Embryogenesis*□S

All living cells rely on intermediary metabolism to maintain an adequate state of energetics. Considerable progress has been made over the last century in defining many of the pathways and regulatory mechanisms of intermediary metabolism. Following from this mechanistic understanding, much insight has been gained into how organisms modulate the metabolism of their various cell types to achieve ...

Role of insulin in the intermediary metabolism of the activated thymic-derived lymphocyte.

The hypothesis that a role for insulin in the metabolism of T cells would be evident after cell activation when receptors appear was tested to validate the T cell model and to analyze the mechanism by which insulin may function in immunoregulation. Measuring the flux rates of 3-O-[methyl-3H]-D-glucose and aminoisobutyric acid, alpha-[1-14C], lactate production and oxidation, and glucose oxidati...

Preservation of intermediary metabolism in saponin-permeabilized rat adipocytes.

A unique permeabilized adipocyte model is described in which vigorous intracellular intermediary metabolism is preserved through both the pentose and glycolytic-Krebs pathways following saponin-induced pore formation in plasma membranes. Upon addition of appropriate cofactors, the cells metabolize both glucose and glucose 6-phosphate at rates which are severalfold greater than control (membrane...

Intercurrent illness in inborn errors of intermediary metabolism.

Metabolic decompensation may occur in patients with disorders of intermediary metabolism during intercurrent illness. To prevent complications it is normal practice to change the diet to an 'emergency regimen'. The mainstay of this is a high carbohydrate intake, using soluble glucose polymer, given as frequent drinks by day and during the night. Additional therapy is given for some disorders. P...

Effects of Inorganic Iodide on the Intermediary Carbohydrate Metabolism of Surviving Sheep Thyroid Slices.